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Consistent with this study, deletion of Zim17, an important component of ISC biogenesis, leading to genomic instability (Diaz de la Loza Mdel et al., 2011

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Apart from the GSH-GPX4 inhibitory pathway, which is recognized as the predominant ferroptosis regulatory system (31), one such mechanism involves ferroptosis suppressor protein 1 (FSP1, also known as AIFM2), which inhibits lipid peroxidation and ferroptosis by synthesizing panthenol and rejuvenating oxidized -tocopherol radicals (vitamin E) (32,33)

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20,21 Chronic use of inhaled hypertonic saline is recommended for patients aged 6 years and older for improved lung function and quality of life, and reduced exacerbations