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Due to limited research, the roles of GPx5, GPx6, and GPx8 in tumorigenesis are still awaiting clarification
An age-related decline in these systems, termed non-radical drift, narrows the protective window for oxidative eustress, making tissues more susceptible to both the pro-cancerous effects of chronic oxidative stress and other age-related pathologies [248, 249]

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Cen P, Hofstetter WL, Correa AM, Wu TT, Lee JH, Ross WA, Davilla M, Swisher SG , Fukami N, Maru D, Rashid A, Ajani JA