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Germline mutations in BRCA1/2 hamper the DNA repairing ability, progressing to genomic instability and malignant transformation

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Rabbits were fed with 100 g daily of a standard rabbit chow (Alimentos Protinal C.A., Valencia, Venezuela) with a partial composition of 19 % of crude protein (minimal), 2% of crude fat (minimal), 10% of crude staple (maximum) and 40% of free nitrogen extracts (minimal), and water "ad libitum"

doi: 10.3389/fimmu.2026.1758379 Received 01 December 2025 Revised 05 March 2026 Accepted 05 March 2026 Published 28 April 2026 Volume 17 - 2026 Edited by Varun Sasidharan Nair, Italian Institute of Technology (IIT), Italy Reviewed by Mahmoud Abdelrahman Alkabbani, Egyptian Russian University, Egypt Lingjie Meng, Zunyi Medical University, China Updates Copyright 2026 Sivalingam

Commandeur (Vrije Universiteit Amsterdam) for his helpful advice and comments