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doi: 10.1016/j.metabol.2021.154886 118 SkjaerbaekCFrystykJOrskovHKissmeyer-NielsenPJensenMBLaurbergSet al

Simple Explanation of Half-Life Half-life refers to the amount of time it takes for half of a substance to leave the bloodstream or become metabolized by the body

No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Careful patient selection is essential

However, it is worth emphasizing that the chemical form of selenium used and its concentration are crucial in this regard