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o In September 2025, Rybelsus (oral semaglutide) received an EU label update based on the SOUL trial, making it the first and only oral GLP-1 RA with proven cardiovascular benefits, having demonstrated a 14% reduction in cardiovascular death, heart attack, and stroke in high-risk type 2 diabetes patients
Australian Broadcasting Corporation
Cagrilintide directly activates brain satiety centers via amylin pathways, while semaglutide works by slowing gastric emptying and increasing insulin secretion
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