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Lymphatic targeting may be achieved via the delivery of macromolecular therapeutics (for example, proteins and peptides), small-molecule therapeutics in association with macromolecular carriers (for example, nanoparticles, polymers, liposomes and dendrimers) or small-molecule therapeutics that associate, in situ , with endogenous macromolecular constructs (for example, lipoproteins and proteins) or cells that are transported from interstitial tissues via lymphatic rather than blood capillaries

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An intensity-dependent relationship was found between ammonia levels and exercise, which suggested that ammonia accumulation exhibits a pivotal role in both physical and mental fatigue (41)

Toxicol Appl Pharmacol 214(2):99108

In addition to ion pumps and the cell wall, multicellular organisms have evolved another strategy to counter osmotic forces: surrounding cells with a solution that is isotonic, or nearly isotonic, with respect to the cytosol