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The NLRP3 inflammasome, closely related to CRC, is activated by TMAO-induced endothelial inflammation mediated by mitochondrial reactive oxygen species (ROS) (Yue et al., 2017)

The total SF-36 scores, especially the physical component scores, PHES scores, and the rate-correct scores of the inhibition test were improved within the L-carnitine group after 24 weeks of treatment (Supplementary Table 3)
L-carnitine works best when your body has a high energy demandmeaning you need to move to reap the benefits

10.1073/pnas.0601056103 44 TurckD.BressonJ
