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Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies

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In addition, increasing neutrophils may contribute to the progression of AS through phagocytosis, ROS production damaging tissue and impairing endothelial function, repairing damaged tissues, restricting NET production, or directly releasing NET to counter inflammation, which may be beneficial for the progression of AS (32, 61, 203)

TFA treatment specifically increased the abundance of Streptococcus, Streptococcus, pneumoniae, and Staphylococcus epidermidis (Figure 3D)
