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Moreover, surface modification can reduce mucociliary clearance, increase drug residence time in the olfactory region, enhance permeability and bioavailability, and improve active brain-targeting capabilities

Diabetes Care Ferrannini, E

This leads to the indirect activation of v-raf murine sarcoma viral oncogene homolog B1 (RAF) kinases, which can subsequently activate the MAPK effector kinase MEK and finally MAPK, which can then translocate to the nucleus to activate transcription factors responsible for regulating a large number of genes

10.3390/su14116847 46 DhamiM

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