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NLRP3 inflammasome activates caspase-1 to cleaves pro-IL-1 and pro-IL-18 into the active forms IL-1 and IL-18, meanwhile, cleaves the amino-terminal fragment of the key protein gasdermin D (GSDMD) to form N-GSDMD, which oligomerizes and forms membrane pore formation leading to pyroptosis and subsequent inflammatory response

2014;9:e97880

& Shapiro, I

Glutathion ist ein krpereigenes Tripeptid, das in nahezu allen Zellen des menschlichen Organismus vorkommt
