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Moreover, these barriers regulate the transport of iron from the bloodstream to the brain parenchyma, helping to maintain brain iron levels largely independent of systemic iron levels and providing protection against systemic iron toxicity (37,38)

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10.1016/j.ceb.2010.10.012 Curr Opin Cell Biol

Detoxification Xenobiotic Agents Numerous foreign compounds, including drugs, are so hydrophobic that they would remain in the body indefinitely were it not for hepatic biotransformation

Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis