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Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease

( 3) Interestingly, B12 is used as part of the process in making these phospholipids

There are essentially two exit fluxes of the methionine cycle: One is the exchange of methionine with blood, the other is the flux of homocysteine to cysteine

8.2.1 Dexamethasone-loaded NPs Dexamethasone is a potent anti-inflammatory steroid that can modulate neuroinflammation, a critical factor in PD progression (169)

440 These medications are administered orally or topically, in the form of pills, rectal suppositories, or enema fluids