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Animal experiments were subject to ethical review by the Francis Crick Animal Welfare and Ethical Review Body and carried out under UK Home Office project license P319AE968 or by the CRUK Beatson Institute (reviewed and approved by the University of Glasgow and UK Home Office) and carried out under UK Home Office project license 70/8645

Coupling these with in vitro and in vivo experiments using primary human articular chondrocytes and cartilage-specific Igf1 CART-KO mice, we unraveled that Wnt signaling transcriptionally induces IGF1, which drives detrimental joint changes in osteoarthritis

Leveraging the power of transdermal ingredient delivery, the body's overall absorption of their antioxidant and vitamin content is much greater

Front Nutr 8:717343

doi: 10.1038/nchem.1155