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In many cell types, pyruvate carboxylation to oxaloacetate is suppressed, thereby rendering them reliant on glutamine catabolism to replenish the oxaloacetate that can condense with acetylCoA to produce citrate and drive the TCA cycle (DeBerardinis et al , 2007)

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Robert Nussbaum, Beth Crawford, Kate Loranger, Julie Mak, Nicola Stewart, Robin Lee, Amie Blanco and Peggy Conrad and Salina Chan

Bufalin exacerbates photodynamic therapy of colorectal cancer by targeting SRC-3/HIF-1 pathway

In addition, the activation of the PI3K/AKT/mTOR pathway has been implicated in the development of resistance to RAI therapy in thyroid cancer, and this pathway is known to upregulate glycolytic enzymes [31]