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subsequently, glutamate will convert to -ketoglutarate (-KG) as the main component of Tricarboxylic Acid cycle (TCA) by mitochondrial glutamate dehydrogenases (GLUD), -KG mainly incorporates into TCA cycles to assist the production of NADPH and nucleotide synthesis

Borthakur G , Lin E, Jain N, Estey EE, Cortes JE, O'Brien S, Faderl S, Ravandi F, Pierce S, Kantarjian H

Moreover, many tumors including PCa cells shed DNA into the serum or other easily accessible body fluids (e.g., semen, urine), simplifying the detection of GSTP1 epimutations in early tumorigenesis stages

J Biol Chem 280, 1418914202, 10.1074/jbc.M413660200 (2005)

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