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The honest answer is: it depends on the person, but the risk is never zero, and the idea that one drink is always harmless does not hold up well under scrutiny

The experimental mice were housed under standard conditions with an environmental temperature of 23 C 2 C and humidity of 50% 5%

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Peroxynitrite as regulator of vascular prostanoid synthesis

Because longterm human studies are lacking, there are concerns about unknown immune, cardiovascular, or proliferative effects, and some experts warn that users may face unpredictable risks, especially with unsupervised use