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Cell 50 , 658671.e7 (2019)

Arch Intern Med 2002

Melatonin Physiology Seasonal Rhythms A truly distinct physiological role for melatonin was initially indicated by the fact that pinealectomy or ganglionectomy (which abolished the rhythm of circulating melatonin) abolished the ability of photoperiodic mammals to time seasonal physiology according to the day length (with very rare exceptions) (39, 40)

Activated by the PI3K/Akt pathway, mTORC1 is closely linked to the expansion of proinflammatory T cells, supporting glycolysis and differentiation into Th1 and Th17 cells while limiting their differentiation into Treg cells
