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[,] Although one in three PBC patients who are treated with UDCA have no response to therapy, UDCA is still considered the first therapeutic choice for PBC

[48] [37] : Preface It is based primarily on his work in this area that he received the Nobel Prize in Chemistry in 1954 "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances"

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Squarci C., Bianco P., Reconditi M

The mechanism of normalizing retina blood flow by vitamin E was evaluated using animal studies and involves the diacylglycerol (DAG) activating protein kinase C (PKC) through binding to isozyme C1 domains (Koya et al