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For L-carnitine, rigorous studies focusing on exercise performance and muscle fatigue frequently utilize daily doses ranging from 1,000 mg to 3,000 mg to achieve significant metabolic shifts

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Chronic excessive intake, particularly when beyond 3 months or at daily doses exceeding 300 g, increases the risk of selenosis (89), whose clinical manifestations may include abdominal symptoms such as vomiting, diarrhea, pain, and nausea as well as a garlic-like odor on the breath (90)