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The newly reformed acyl-CoA is now perfectly positioned to enter the beta-oxidation pathway, a series of chemical reactions that break down the fatty acid chain to generate Acetyl-CoA, NADH, and FADH2

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however, this time all subjects received the placebo, which was also a glass of fruit juice

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Two variants of D-2-HGA have been found: D-2-HGA type I, which is caused by mutations in the D-2-hydroxyglutarate dehydrogenase gene ( D2HGDH ), and D-2-HGA type II, caused by gain-of-function mutations in the isocitrate dehydrogenase II ( IDH2 ) gene