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Iwata, K

P., Hochman-Mendez C

O'Brien ML, Vulevic B, Freer S, Boyd J, Shen H and Tew KD

These genomes also display elevated levels of recombination and structural variability, including an abundant presence of insertion sequence (IS) elements, genomic islands, constituting 56% of the genome, and chromosomal rearrangements such as inversions, transpositions, duplications, and deletions (Loutet and Valvano 2010

Although this analysis shows that these ferroptosis-related genes are differentially expressed in App NL-G-F knock-in AD mice, it is known that downregulation of Gpx4 and upregulation of Acsl4 can induce ferroptosis ( Gpx4 ) and depleting the substrates for lipid peroxidation (as Acsl4 gene expression was found decreased) (Stockwell et al., 2017)
