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Vitamin B12 deficiency Having trouble absorbing vitamin B12 from food, lacking intrinsic factors (for example, as a result of pernicious anaemia), having gastrointestinal surgery, taking certain medications for an extended period of time (such as metformin or proton pump inhibitors), and nutritional deficiencies are all causes of vitamin B12 deficiency

doi: 10.1038/s41467-024-51207-x 56 SiddiquiFAPrakasamGChattopadhyaySRehmanAUPadderRAAnsariMAet al

Also high-valent chromium(VI) is able to generate reactive ROS during its conversion to the stable Cr 3+ oxidation state [13] and this mechanism has been associated to the recognized carcinogenic activity of chromate salts [14]