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IKEMA and CANDOR Results from a phase Ib study (NCT02332850) indicated that isatuximab combined with carfilzomib was clinically active in heavily pretreated RRMM patients [72]

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NF-B has been shown to trigger proapoptotic processes in retinal pericytes under high glucose stress, which may account for the early onset of pericyte death in DR (93)

These can result from hemorrhage, decompensated liver cirrhosis, treatment with non-steroidal anti-inflammatory drugs, congestive heart failure, and renal artery occlusion or stenosis
