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Combination of PI3K- and CDK4/6-inhibitors overcame the intrinsic and acquired resistance of breast cancers to PI3K-inhibitors, and resulted in regression of PIK3CA -mutant xenografts (88)
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Furthermore, preclinical studies have demonstrated synergistic effects when FSEN1 was used alongside endoperoxide-derived ferroptosis inducers, such as dihydroartemisinic acid (101)
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