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Targeting PGAM5 in tumor cells reduces mitochondrial DNA stress and suppresses M2 polarization via the TLR9/NF-B/CCL2 axis, significantly improving the efficacy of immunotherapy in liver cancer (279)

Interestingly, we found no significant difference among studied administrated routes in all other CBC parameters such as Hb, MCV, platelets count, WBC count, and homocysteine level

The dismutation of superoxide can also occur spontaneously, but such reaction is 10 4 times slower than the enzymatic dismutation by SOD2

E.PorrasC.HerreroR.GradissimoA.et al

Although direct experimental evidence in fibrosis-to-tumor transition is limited, these observations suggest that SPP1 + macrophages may similarly sustain immunosuppressive, pro-invasive niches in fibrotic regions, providing a testable hypothesis for future studies