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Depending on cellular state and stress cues, TP53 can promote ferroptosis by repressing SLC7A11 to limit cystine uptake and GSH synthesis, inducing spermidine/spermine N1-acetyltransferase 1 ( SAT1 ) to enhance ROS generation through polyamine catabolism, and upregulating glutaminase 2 ( GLS2 ) to increase -ketoglutarate production and mitochondrial ROS 154-156

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Currently, stem cell vesicle therapy is gradually developing as an alternative to cell therapy and has gained widespread attention in intervertebral disc degeneration (IDD) repair

10.1016/S0304-3940(03)00558-5 257 SilesA

Most importantly, numerous other neuroprotective and neurotrophic growth factors like BDNF-analogs and LM11A-31 are currently being studied for their cognitive and therapeutic benefits, especially their ability to preserve and promote neural networks and neuron health, particularly in the setting of neurodegenerative diseases like Alzheimer's disease, FrontoTemporal Dementia (FTD), Parkinson's Disease (PD), and Lewy-Body Disease, as well as ischemic or traumatic neural injury (68a) (68b) (68c) (68d)