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High doses of B12, often used to treat deficiencies, may cause side effects such as headaches, nausea, diarrhea, fatigue or weakness, and tingling in the hands and feet

Gabapentin, pregabalin, antidepressant-type pain modulators, lidocaine, or capsaicin may reduce nerve sensitivity, but they may not fully help if local irritators remain active

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Vitamin B12 is essential for: Energy production Red blood cell formation Nervous system function Brain health and concentration When B12 levels are low, the body struggles to produce energy efficiently, leading to fatigue and other symptoms

Many people report feeling more energetic within a few days, while others notice gradual improvement over one to two weeks