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Post-acute sequelae of COVID (PASC), otherwise known as Long-COVID, can be attributed to these microclots which block transport of erythrocytes in capillaries and therefore oxygen delivery [6]

The annulus fibrosus forms the outer ring, a complex series of fibrous layers made primarily of type I collagen arranged in alternating diagonal patterns

This leads to disruptions in the transcription of proteins vital to the mitochondrial ETC, thus inducing malfunction and hindering ATP synthesis, which in turn might escalate ROS generation [113]

We selected the murine BALB/c strain because it provides a more consistent response to infection, and is less vulnerable to pneumococcal infection compared to other mouse strains