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These inflammatory mediators might stimulate nociceptors, leading to generation and further chronification of painful symptoms

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(5) A Nakamura, M Nakashima, T Sugao, H Kanemoto, et al (1988) Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP) European Journal Pharmacology, 1988 Oct 18, Volume 155 (Issue 3), Pages 247-53

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