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During a median follow-up of 9 years (range 1 month to 33.2 years), 202 patients developed metastasis

According to major international guidelines, low-dose combined hormonal contraceptives (CHCs) and progestogens are standard first-line treatments for symptomatic endometriosis, effective in approximately two-thirds of symptomatic women ( Combined oral contraceptives (COCs) are commonly used off-label to suppress ovarian function and reduce symptoms, though evidence supporting their effectiveness is less robust, with about 50% of patients reporting partial or no symptom improvement

Our results show that both pre- and post-treatment with the anthocyanin-enriched fraction induced a reduction of ROS generation induced by AAPH (Figure 5A)

99 Importantly, these natural compounds possess a remarkable antioxidant activity, and this effect is realized by activating the Keap1-Nrf2 pathway