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Because its effects result from changes in gene expression, therapeutic responses typically require several hours to develop

This is more speculative, but it's a valid avenue of inquiry

Such a particular activity in angiogenesis and healing is concordant with the previous evidence that BPC 157 may directly protect endothelium (13), influence NO-system, counteract the effect of NOS-inhibitor and NO-precursor (14, 15), as well as over expression of endothelin (16)

Glutathione conjugation takes place between the drug and sulphhydryl group (SH) of glutathione (Figure 14)

Once-daily dosing offers simplicity and better compliance, while split dosing theoretically maintains more stable tissue concentrations throughout the day