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The dietary intake and bioavailability of coenzyme Q10 are low and therefore it has been recommended to be administrated by supplements (Duarte-Jurado et al

Regarding tumor metabolic adaptation, natural product delivery systems can be engineered to target key metabolic pathways

Luminal A is the most common molecular subtype of breast cancer, accounting for approximately 50% of invasive breast cancer cases [2], and is characterized as estrogen receptor-positive (ER+), progesterone receptor-positive (PR+), HER2/Neu-negative, with low Ki-67 expression [3]

As Kannt & Pfenninger highlight in Frontiers in Physiology , maintaining NAD levels is a cornerstone of metabolic health, supporting mitochondrial function and improving resistance to metabolic stress (Kannt & Pfenninger, Frontiers in Physiology )

In summary, advancing our understanding of mitochondrial carrier functions and their regulatory mechanisms in cancer will be essential for developing novel therapeutic strategies