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"Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase." Journal of Medicinal Chemistry

It burns through nicotinamide, which your cells would otherwise recycle into NAD+, and it spends SAM, the body's main methyl currency

David Sinclair, a leading voice in longevity research, has stated: NAD+ is the closest we've gotten to a fountain of youth.[2] His research highlights how NAD+ activates pathways that mimic caloric restriction, a known extender of lifespan in models

Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide

[1] [3] Some medications, such as chloramphenicol, may interact with B12 therapy