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Stimulation of Nrf2 by the lipid peroxidation product 4-hydroxy-2-nonenal (4-HNE) is involved in neuro- and cardio-protection against oxidative stress after ischemic preconditioning (Calvert et al., 2009

We identified 7 differentially methylated CpGs (FDR 0.01) in over 5% of the samples, 2) overlapped with a SNP at the measured or extension site or 3) cross-hybridized to other genomic locations

The best compound was the pomalidomide-based PROTAC 23 , which was able to degrade targets with nanomolar potency (DC 50 value of 102 nM) and inhibit cell proliferation (IC 50 value of 2.2 M) of HCT116 cancer cells

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Additionally, paeonol reduced the production of ROS and upregulated HO-1