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According to the exploration results of the T1D patients or models, the following bacteria were mainly increased in abundance: Bifidobacterium longum (166, 167), Eubacterium rectale (168), Bacteroides uniformis (169), Lachnospira spp., Intestinimonas spp., Micrococcales spp (170)., Actinomyces spp (171)., Bacteroides spp (172)., Prevotella spp (168)., Ruminococcus spp (173)., and Veillonella spp (174)., whereas the bacterium with decreased abundance mainly includes butyrate-producing bacterium, lactic acid-producing bacterium, and mucin-degrading bacterium, such as Lactococcus , Lactobacillus ( 173), Streptococcus (174), Bifidobacterium , Proteobacteria (172), Subdoligranulum , Roseburia , Eubacterium , Anaerostipes (175), FP (176, 177), Clostridium clusters IV (178, 179), and XIVa (180, 181)

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About This Issue Abstract Case Presentations Introduction Critical Appraisal of the Literature Etiology and Pathophysiology Etiology Hypothyroidism Hyperthyroidism Pathophysiology Differential Diagnosis Decompensated Hypothyroidism Thyroid Storm Prehospital Care Emergency Department Evaluation Stabilization History Decompensated Hypothyroidism Thyroid Storm Physical Examination Decompensated Hypothyroidism Thyroid Storm Diagnostic Studies Thyroid Hormone Levels Other Diagnostic Tests Electrolyte and Glucose Levels Cardiac Testing Treatment Decompensated Hypothyroidism Thyroid Storm Special Circumstances and Populations Airway Considerations Pregnant Patients Neonatal Hypothyroidism and Thyrotoxicosis Pediatric Patients Controversies and Cutting Edge Subclinical Hypothyroidism Disposition 5 Things That Will Change Your Practice Risk Management Pitfalls for Patients With Thyroid Emergencies Summary Time- and Cost-Effective Strategies Case Conclusions Clinical Pathways Clinical Pathway for Emergency Department Patients With Decompensated Hypothyroidism Clinical Pathway for Emergency Department Patients With Thyroid Storm Tables and Figures References Abstract Patients experiencing thyroid emergencies can present with a wide array of clinical presentations and comorbid conditions, so a systematic strategy to identify key historical and physical examination features can help guide the emergency clinician in recognizing these infrequent conditions

Chin-Hao Chang and the staff of National Taiwan University Hospital-Statistical Consulting Unit (NTUH-SCU) and Dr

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