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Unlike human growth hormone, which can induce hyperglycemia and reduce insulin secretion during extended use, AOD-9604 showed no adverse effect on insulin sensitivity even in long-term animal studies confirmed through euglycemic clamp techniques

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Certain congenital conditions, such as hereditary intrinsic factor defects and congenital vitamin B12 malabsorption (Imerslund-Grsbeck disease), can also cause severe vitamin B12 deficiency

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