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Research published in *Neurogastroenterology & Motility* demonstrated that KPV improved irritable bowel syndrome symptoms in 72% of patients within four weeks (Manzini et al., 2021)

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-Based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
10.1016/j.jconrel.2022.04.003 49 KlotzA
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doi: 10.1371/journal.pone.0155070
