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Absent Fn3K, NRF2 is glycated, a post-translational modification which enhances KEAP1-driven degradation, impairs NRF2 binding to transcriptional cofactors sMAF, reduces NRF2 binding in the promoter region of target genes, and leads to reduced transcription of canonical NRF2 pathway genes [87]

2021JJ41008), the Key Project of Changsha Science and Technology Plan (No

By elucidating the complex interplay between ALDH2 and ferroptosis, the present review aims to provide new insights for the development of innovative therapeutic strategies to mitigate ischemic tissue damage and improve clinical outcomes

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Emerging roles of vascular endothelium in metabolic homeostasis