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Surgical Ligation The shunting vessel is identified by midline laparotomy and narrowed or completely occluded by a nonabsorbable ligature

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Regardless of the cause of AD, elevated oxidative stress has been observed in AD, which contributes to disease progression (Torres et al., 142 , which is generated by the cleavage of amyloid precursor protein (APP), by enzymes such as -secretase 1 (BACE1) and increases oxidative stress

& Badraoui, R

The C677T variant lowers the affinity of MTHFR and its cofactor, which promotes the thermolability and diminishes the enzyme activity