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Sickle cell anemia: The hematologist will consider treatment options such as giving oxygen, pain relievers, intravenous fluids to reduce pain and prevent complications, blood transfusions, folic acid supplements, and antibiotics

Dev Dyn 218: 213-234

doi: 10.1016/j.biochi.2012.11.004

Yes, B12 supplementation is appropriate if deficiency is confirmed, and the MHRA recommends monitoring B12 levels in people on long-term metformin

Vernet P, Rigaudiere N, Ghyselinck N, Dufaure JP, Drevet JR
