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In parallel, excessive Cu + generated in GSH-rich reductive environments can bind lipoylated mitochondrial TCA-cycle proteins such as DLAT, inducing aberrant protein aggregation and triggering cuproptosis across multiple cancer types 187,189,192-194

In the MVP cohort 20 , rs10305420 is associated significantly with BMI-associated traits ( P value around 2 10 15 ), although it is in linkage with an upstream association (Extended Data Fig

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