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Specific degrees of burns are distinguished: the first degree involves only the epidermis on the surface of the body, the second degree includes all layers of the epidermis and part of the dermis beneath the epidermis, and the third degree involves all layers of the skin and epidermis reaching the subcutaneous connective tissue

Research protocols typically employ intermittent dosing strategies (once weekly or 3-day cycles) designed to prevent excessive apoptosis while enabling effective senescent cell elimination, with doses ranging from 5-10 mg/kg body weight in animal studies

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