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Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms
Chaput M., Ness B

Kopriva et al., 2012)

doi: 10.1089/ars.2023.0237
Fourth, regarding the microbiota-lipid-depression mediation hypothesis, human intervention data are scarcemost evidence [e.g., (8890) on lipid transformation] comes from germ-free mouse models, but the diversity of the human gut microbiota (e.g., ~1,000 species vs
