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Methods: We first established a silicosis mouse and employed a combination of histological examination, Western blot analysis, immunofluorescence, and single-cell RNA sequencing to clarify the relationship between oxidative stress vascular endothelial mesenchymal transition (EndMT), and Tet concentration in lung tissue

C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila

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48-50 The major clinical manifestations and complications of PNH are those associated with hemolytic anemia, thrombosis, and bone marrow failure ( Box 24-2 )

A two-step progression from simple steatosis to steatohepatitis and fibrosis has been proposed 13 , and suggests that after fat accumulation in the liver due to insulin resistance, lipids are peroxidized with cytokines and Fas ligand induced by excessive ROS