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Medical Conditions Those with kidney disease, a history of kidney stones or certain metabolic disorders (such as G6PD deficiency) should consult a doctor before receiving IV vitamin C, as high doses could pose health risks

Yoshitani M, Fukuda S, Itoi S, et al

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For instance, combining Kla inhibitors with immune checkpoint inhibitors, standard chemotherapy/targeted therapies, and drugs targeting key glycolytic enzymes may open up new avenues for overcoming drug resistance and immune evasion in cancer treatment

doi:10.2353/ajpath.2008.070429 Dinic S, Arambasic J, Mihailovic M, Uskokovic A, Grdovic N, Markovic J, Karadzic B, Poznanovic G, Vidakovic M (2013) Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of alpha-lipoic acid in diabetic liver