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Cortes J, Kantarjian H, OBrien S, Beran M, Estey E, Koller C, Andreeff M , Kornblau S, Keating M, Freireich EJ, Talpaz M

A very small minority of the cAP harvested from cells is active, and we have shown that this background activity primarily derives from a small fraction that, despite the absence of the N-terminal leader sequence, is nevertheless exported and oxidized by the periplasmic disulfide-bond forming system (Dsb) (Eben and Imlay, 2023)