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The reaction is catalysed by uridine diphosphate glucuronosyltransferase (UGT) which is mainly present in liver and adjacent to CYP-450 in the endoplasmic reticulum (ER) of the liver

Rather than viewing aging as simply getting older, scientists now recognize aging as a biological process driven by cellular dysfunction, chronic inflammation, mitochondrial decline, hormonal changes, DNA damage, stem cell exhaustion, and loss of tissue repair capacity

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Rheumatology (Oxford) 49 , 231239, doi:10.1093/rheumatology/kep384 (2010)