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PYRIN senses bacterial toxins that modify and inactivate Rho GTPases, and PYRIN dephosphorylation and microtubule polymerization are thought to participate in inflammasome assembly [308]

Neuroscience 335:207220 Mosley RL, Benner EJ, Kadiu I, Thomas M, Boska MD, Hasan K, Laurie C, Gendelman HE (2006) Neuroinflammation, oxidative stress and the pathogenesis of Parkinsons disease

The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets

doi: 10.1038/clpt.1991.209

Kidney Dysfunction: High doses over a prolonged period could potentially strain the kidneys, especially in individuals with pre-existing kidney conditions