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This research has been supported by the National Key Research and Development Program of China (grant no

K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A

Oleocanthal Oleocanthal (Oc), a dialdehydic derivative of decarboxymethyl elenolic acid bound to Tyr, ( p -HPEA-EDA) was shown in vitro to inhibit both COX-1 and COX-2, inflammatory enzymes involved in the biosynthesis of inflammatory prostaglandins in a dose-dependent manner, and to be more effective than ibuprofen in inhibiting these enzymes at equimolar concentrations [260] (see Figure 1)

Both blends share three components but differ significantly in their inflammatory action

Additionally, chronic alcohol intake can inhibit the Nrf2-ubiquinol cytochrome c reductase core protein 2 (UQCRC2) pathway and suppress mitophagy activity by downregulating adenosine monophosphate-activated protein kinase (AMPK) gene expression