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Quercetin: a functional dietary flavonoid with potential chemopreventive properties in colorectal cancer

The field needs validated, in vivocompatible flux sensors (O 2 , H 2 O 2 , NO/ONOO ) targeted to matrix/IMS, ER lumen, peroxisomes, plasma-membrane microdomains and nucleus, each with built-in specificity controls and reporting standards (matrix, oxygen tension, m, pH) to disambiguate signalling pulses from damage plateaus

However, recent research has indicated that epigenetic abnormalities can also lead to the inactivation of tumor suppressor genes and activation of proto-oncogenes, playing a crucial role in the initiation, progression, invasion, and spread of cancer (Feinberg and Levchenko, 2023) (Figure 1)

Synthetic cannabimimetics (e.g., Spice, JW) also pose a great risk to users and athletes